早筛网讯：近日，国家癌症中心中国医学院科学院肿瘤医院崔巍教授与顶级多组学技术团队合作在消化道领域国际顶级期刊《GUT》杂志发表题为“Integrated analysis of the fecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma”的原创研究[1]。
与此同时在国内，中精普康公司提前布局在对血清代谢物预测肠道菌群状态来诊断早期疾病风险的技术方向。通过检测血清中肠道“促瘤菌群”和“抑瘤菌群”直肠肿瘤相关代谢物的相对丰度变化进行模型分析，自主研发的早长静®检测，（CASM，一款无创、非侵入性血清质谱检测产品），采用液相色谱-串联质谱法(LC-MS/MS)，结合自主研发专利GMSM肠道菌群代谢物多组学模型，对血清中的肠道菌群结直肠肿瘤相关代谢物进行检测分析，显著提高了早期结直肠肿瘤及癌前病变的检出率，其
数千例样本数据显示敏感性94.2%，特异性92.5%。验证组AUC达到0.92，阳性预测值0.91。使得对结直肠肿瘤的早期发现和癌前病变真正成为可能。 参考文献[1] Feng Chen, Xu-Dong Dai, Chang-Chun Zhou, et al. Integrated analysis of the fecal metagenome and serum metabolome reveals the role of gut microbiome-associated metabolites in the detection of colorectal cancer and adenoma. Gut 2021;0:1-11.doi:10.1136/gutjnl-2020-323476[2] Yachida, S.et. al. (2019) Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer, Nature medicine. 25, 968-976.[3] Pleguezuelos-Manzano, C., Puschhof, J., Rosendahl Huber, A. et al. (2020) Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli. Nature 580,269–273.
